Pathogenesis and approaches to therapy of membranoproliferative glomerulonephritis
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چکیده
منابع مشابه
Pathogenesis and approaches to therapy of membranoproliferative glomerulonephritis.
In 1965, it was observed that patients with glomerulonephritis with persistently low serum concentrations of C3 evolved to have similar glomerular morphologic characteristics, particularly recognizable in biopsy specimens stained by the Jones methenamine silver technique [1]. Subsequent observations have indicated that although long-standing hypocomplementemia is commonly observed and is unique...
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Membranous glomerulonephritis is characterised by accumulation of immune complexes on the outside of the glomerular basement membrane. This leads to development of projections of the membrane adjacent to the deposits which eventually become incorporated into the membrane. In about 20% of cases the disease occurs in association with another condition such as SLE, cancer or drug exposure. The rem...
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Membranoproliferative glomerulonephritis (MPGN) refers to glomerular pathology in which there is thickening of the capillary wall together with mesangial expansion. In this article we firstly review the pathological features of MPGN and discuss how advances in our understanding of the association between abnormalities in the regulation of complement and MPGN have revealed limitations in the his...
متن کاملMembranoproliferative glomerulonephritis.
Glomerulonephritis (GN) encompasses a wide variety of primary and secondary diseases that cause injury to the functioning unit of the kidney, the glomerulus. The many classifications of GN sometimes lead to confusion. This case study describes an individual with membranoproliferative GN and includes discussion of classification, treatment, and prognosis of this disease.
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The reports of glomerular lesions of kidney due to tuberculosis are sparse. A 48-year-old gentleman, presented with swelling of feet of 3 months duration. As he had renal impairment, proteinuria and normal-sized kidneys, he was subjected to renal biopsy. The light microscopy and immunofluorescence revealed the diagnosis was membrano-proliferative glomerulonephritis. During hospital stay, the pa...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1976
ISSN: 0085-2538
DOI: 10.1038/ki.1976.1